Neurobiology of Disease PDZ Protein Interactions Underlying NMDA Receptor- Mediated Excitotoxicity and Neuroprotection by PSD-95 Inhibitors
نویسندگان
چکیده
Hong Cui,3 Amy Hayashi,1 Hong-Shuo Sun,1 Michael P. Belmares,2 Carolyn Cobey,2 Thuymy Phan,2 Johannes Schweizer,2 Michael W. Salter,3,5 Yu Tian Wang,6 R. Andrew Tasker,4 David Garman,2 Joshua Rabinowitz,7 Peter S. Lu,2 and Michael Tymianski1,3 1Toronto Western Hospital Research Institute, Toronto, Ontario, Canada M5T 2S8, 2Arbor Vita Corporation, Sunnyvale, California 94085, 3NoNO Inc., Toronto, Ontario, Canada M8X 1R5, 4Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada C1A 4P3, 5Programme in Brain and Behaviour, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8, 6Brain Research Center and Department of Medicine, Vancouver Hospital and Health Sciences Center, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3, and 7Lewis Sigler Institute for Integrative Genomics and Departments of Molecular Biology and Chemistry, Princeton University, Princeton, New Jersey 08544
منابع مشابه
PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors.
In neuronal synapses, PDZ domains [postsynaptic density-95 (PSD-95)/Discs large/zona occludens-1] of PSD-95 proteins interact with C termini of NMDA receptor [NMDAR (NR)] subunits, linking them to downstream neurotoxic signaling molecules. Perturbing NMDAR/PSD-95 interactions with a Tat peptide comprising the nine C-terminal residues of the NR2B subunit (Tat-NR2B9c) reduces neurons' vulnerabili...
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